Preheat the oven to 400°F (200°C) and line a baking sheet with parchment paper.
In a large mixing bowl, whisk together the flour, granulated sugar, baking powder, and salt until well combined.
Add the cubed cold butter to the flour mixture. Use a pastry cutter or your fingers to work the butter into the flour until the mixture resembles coarse crumbs.
Stir in the dried cranberries and orange zest until evenly distributed.
In a separate bowl, whisk together the heavy cream, egg, and vanilla extract.
Pour the wet ingredients into the dry mixture and gently fold until just combined. Be careful not to overmix; the dough should be slightly sticky.
Turn the dough out onto a lightly floured surface and shape it into a disc about 1-inch thick. Cut the disc into 8 wedges and place them evenly on the prepared baking sheet.
Bake in the preheated oven for 15-18 minutes or until the scones are lightly golden on top.
While the scones are baking, prepare the glaze by whisking together the powdered sugar, orange juice, and orange zest in a small bowl until smooth.
Once the scones have cooled slightly, drizzle the orange glaze over the tops using a spoon.
Notes
Serve the scones warm on a decorative plate, garnished with additional orange slices and cranberries for a pop of color.